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KMID : 0903519980410010078
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1998 Volume.41 No. 1 p.78 ~ p.83
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Comparison of Inhibitory Effect of Rice Bran - extracts of the Colored Rice Cultivars on Carcinogenesis
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Abstract
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Anticarcinogenicity of 12 kinds of colored rice cultivars was investigated in vitro with Ilpumbyeo as a control. Pigment and hexane fractions were prepared from the rice brans through extraction with 80% ethanol containing 0.5% TFA or n-hexane to use subsequent evaluation of their anticarcinogenic effect by determining inhibitory activity against DNA strand scission and tumor promotion, as well as antimutagenic activity using SOS chromotest system. Antimutagenic activity of the pigment fractions was revealed to decrease in order of LK1B4-12-1-1 $gt; Sanghaehanghyulla $gt; HP833-1-3-1-1 $gt; Chokoto14 $gt; Jagwangdo $gt; Jajin $gt; Kilmheugmi $gt; Tiwarr-Tsi-C $gt; Heugjinmi $gt; Linsia-Shoea-Dau $gt; Suweon425 $gt; Suweon415. The activity of the hexane fractions decreased in order of LK1B4-12-1-1 $gt; Sanghaehyanghyulla $gt; Ilpunibyeo $gt; HP833-1-3-1-1 $gt; Chokoto14 $gt; Jagwangdo $gt; Jajin $gt; Linsia-Shoea-Dau $gt;Tiwan-Tsi-C $gt; Heugjinmi $gt; Suweon425, Kilimheugmi $gt; Suweoo415. Results showed that inhibitory activity against DNA strand scission in the pigment fractions decreased in order of HP833-1-3-1-1 $gt; Tiwan-Tsi-C $gt; Jajin $gt; Chokoto14 $gt; Suweon425 $gt; Heugjinmi $gt; LK1B4-12-1-1 $gt; Suweon415 $gt; Jagwangdo $gt; Kilimheugmi $gt; Linsia-Shoea-Dau $gt; Sanghaehyanghyulla. On the other hand, the activity of the hexane fractions decreased in order of LK1B4-12-1-1 $gt; Suweon 415 $gt; Kilimheugmi $gt; Chokoto14 $gt; Heugjinmi $gt; Jajin $gt; Suweon425 $gt; Tiwan-Tsi-C $gt; Sanghaehyanghyulla a Linsia-Shoea-Dau $gt; Jagwangdo $gt; HP833-1-3-1-1 $gt; Ilpumbyeo. Experiment using the short-term assay for promotor substance showed that inhibitory activity contained in the pigment fractions against rumor promotor TPA decreased in order of Linsia-Shoea-Dau $gt; Kilimheugmi $gt; HP833-1-3-1-1, Suweon425 $gt; Heugjinmi $gt; Jajin $gt; Chokoto14 $gt; Sanghaehyanghylla $gt; Suweon 415 $gt; LK1B4-12-1-1 $gt; Tiwan-Tsi-C $gt; Jagwangdo.
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KEYWORD
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